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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
KNL1_HUMAN
USC-OGP 2-DE database
:
KNL1_HUMAN
KNL1_HUMAN
General information about the entry
View entry in simple text format
Entry name
KNL1_HUMAN
Primary accession number
Q8NG31
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Kinetochore scaffold 1; AltName: Full=ALL1-fused gene from chromosome 15q14 protein; Short=AF15q14; AltName: Full=Bub-linking kinetochore protein; Short=Blinkin; AltName: Full=Cancer susceptibility candidate gene 5 protein; AltName: Full=Cancer/testis antigen 29; Short=CT29; AltName: Full=Kinetochore-null protein 1; AltName: Full=Protein CASC5; AltName: Full=Protein D40/AF15q14;.
Gene name
Name=KNL1
{ECO:0000312|HGNC:HGNC:24054}
Synonyms=CASC5, KIAA1570
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1285
:
pI=5.42; Mw=25688
Cross-references
UniProtKB/Swiss-Prot
Q8NG31; KNL1_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
KNL1_HUMAN
Primary accession number
Q8NG31
Secondary accession number(s)
Q8NHE1 Q8WXA6 Q9HCK2 Q9NR92
Sequence was last modified on
February 10, 2009 (version 3)
Annotations were last modified on
March 15, 2017 (version 126)
Name and origin of the protein
Description
RecName: Full=Kinetochore scaffold 1; AltName: Full=ALL1-fused gene from chromosome 15q14 protein; Short=AF15q14; AltName: Full=Bub-linking kinetochore protein; Short=Blinkin; AltName: Full=Cancer susceptibility candidate gene 5 protein; AltName: Full=Cancer/testis antigen 29; Short=CT29; AltName: Full=Kinetochore-null protein 1; AltName: Full=Protein CASC5; AltName: Full=Protein D40/AF15q14;
Gene name
Name=KNL1
{ECO:0000312|HGNC:HGNC:24054}
Synonyms=CASC5, KIAA1570
Encoded on
Name=KNL1 {ECO:0000312|HGNC:HGNC:24054}; Synonyms=CASC5, KIAA1570
Keywords
3D-structure
;
Alternative splicing
;
Cell cycle
;
Cell division
;
Centromere
;
Chromosomal rearrangement
;
Chromosome
;
Chromosome partition
;
Coiled coil
;
Complete proteome
;
Disease mutation
;
Kinetochore
;
Mental retardation
;
Mitosis
;
Nucleus
;
Phosphoprotein
;
Polymorphism
;
Primary microcephaly
;
Reference proteome
;
Repeat
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
AF248041; AAF97513.1
; -; mRNA
EMBL
AF461041; AAL67803.1
; -; mRNA
EMBL
AB022190; BAC05691.1
; -; mRNA
EMBL
AF173994; AAM45143.1
; -; mRNA
EMBL
AC022405; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AB046790; BAB13396.1
; -; mRNA
CCDS
CCDS42023.1; -. [Q8NG31-1]
; .
CCDS
CCDS42024.1; -. [Q8NG31-2]
; .
RefSeq
NP_653091.3; NM_144508.4. [Q8NG31-2]
; .
RefSeq
NP_733468.3; NM_170589.4. [Q8NG31-1]
; .
UniGene
Hs.181855; -
; .
PDB
3SI5; X-ray
; 2.20 A; X/Y=234-252
PDB
4A1G; X-ray
; 2.60 A; E/F/G/H=176-226
PDB
4NF9; X-ray
; 2.80 A; A/B=2117-2337
PDB
4NFA; X-ray
; 2.50 A; A=2131-2337
PDBsum
3SI5; -
; .
PDBsum
4A1G; -
; .
PDBsum
4NF9; -
; .
PDBsum
4NFA; -
; .
ProteinModelPortal
Q8NG31; -
; .
SMR
Q8NG31; -
; .
BioGrid
121354; 46
; .
DIP
DIP-36474N; -
; .
IntAct
Q8NG31; 42
; .
MINT
MINT-1194225; -
; .
STRING
9606.ENSP00000335463; -
; .
iPTMnet
Q8NG31; -
; .
PhosphoSitePlus
Q8NG31; -
; .
DMDM
223590239; -
; .
EPD
Q8NG31; -
; .
MaxQB
Q8NG31; -
; .
PaxDb
Q8NG31; -
; .
PeptideAtlas
Q8NG31; -
; .
PRIDE
Q8NG31; -
; .
DNASU
57082; -
; .
Ensembl
ENST00000346991; ENSP00000335463
; ENSG00000137812. [Q8NG31-1]; .
Ensembl
ENST00000399668; ENSP00000382576
; ENSG00000137812. [Q8NG31-2]; .
GeneID
57082; -
; .
KEGG
hsa:57082; -
; .
UCSC
uc010bbs.2; human. [Q8NG31-1]
; .
CTD
57082; -
; .
DisGeNET
57082; -
; .
GeneCards
KNL1; -
; .
GeneReviews
CASC5; -
; .
HGNC
HGNC:24054; KNL1
; .
HPA
HPA026624; -
; .
HPA
HPA049647; -
; .
MalaCards
KNL1; -
; .
MIM
604321; phenotype
; .
MIM
609173; gene
; .
neXtProt
NX_Q8NG31; -
; .
OpenTargets
ENSG00000137812; -
; .
Orphanet
2512; Autosomal recessive primary microcephaly
; .
PharmGKB
PA142672201; -
; .
eggNOG
ENOG410IF9C; Eukaryota
; .
eggNOG
ENOG410XZXJ; LUCA
; .
GeneTree
ENSGT00410000025918; -
; .
HOGENOM
HOG000246954; -
; .
HOVERGEN
HBG080986; -
; .
InParanoid
Q8NG31; -
; .
KO
K11542; -
; .
OMA
MEITRSH; -
; .
OrthoDB
EOG091G0YZU; -
; .
PhylomeDB
Q8NG31; -
; .
TreeFam
TF335517; -
; .
Reactome
R-HSA-2467813; Separation of Sister Chromatids
; .
Reactome
R-HSA-2500257; Resolution of Sister Chromatid Cohesion
; .
Reactome
R-HSA-5663220; RHO GTPases Activate Formins
; .
Reactome
R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere
; .
Reactome
R-HSA-68877; Mitotic Prometaphase
; .
SIGNOR
Q8NG31; -
; .
ChiTaRS
CASC5; human
; .
EvolutionaryTrace
Q8NG31; -
; .
GeneWiki
CASC5; -
; .
GenomeRNAi
57082; -
; .
PRO
PR:Q8NG31; -
; .
Proteomes
UP000005640; Chromosome 15
; .
Bgee
ENSG00000137812; -
; .
CleanEx
HS_CASC5; -
; .
ExpressionAtlas
Q8NG31; baseline and differential
; .
Genevisible
Q8NG31; HS
; .
GO
GO:0001669; C:acrosomal vesicle
; IDA:UniProtKB; .
GO
GO:0000777; C:condensed chromosome kinetochore
; IEA:UniProtKB-SubCell; .
GO
GO:0005829; C:cytosol
; IDA:HPA; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0016604; C:nuclear body
; IDA:HPA; .
GO
GO:0005654; C:nucleoplasm
; IDA:HPA; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0001675; P:acrosome assembly
; NAS:UniProtKB; .
GO
GO:0008608; P:attachment of spindle microtubules to kinetochore
; IDA:UniProtKB; .
GO
GO:0051301; P:cell division
; IEA:UniProtKB-KW; .
GO
GO:0034080; P:CENP-A containing nucleosome assembly
; TAS:Reactome; .
GO
GO:0007067; P:mitotic nuclear division
; IEA:UniProtKB-KW; .
GO
GO:0010923; P:negative regulation of phosphatase activity
; IDA:UniProtKB; .
GO
GO:0034501; P:protein localization to kinetochore
; IDA:MGI; .
GO
GO:0007062; P:sister chromatid cohesion
; TAS:Reactome; .
GO
GO:0071173; P:spindle assembly checkpoint
; IDA:UniProtKB; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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